Drug Hypothesis & Clinical Research Intelligence

Where medical
discovery becomes
strategy.

Foundry One Sciences operates the Medical Research Solitaire Engine — a distributed think engine that maps cross-domain biological insight into actionable drug hypotheses and clinical intelligence.

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Medical Research Solitaire — Foundry One Sciences
Foundry One Sciences
...  we have not stopped looking

The search
never ends.

Foundry One Sciences was built on a single premise: the most important medical breakthroughs don't come from isolated disciplines. They come from the space between them.

The MRS Engine systematically mines the intersections of oncology, cardiovascular science, neurology, and metabolic disease — surfacing drug hypotheses that conventional research silos miss.

From hypothesis to provisional patent to clinical intelligence product, every output from Foundry One Sciences carries the weight of a system designed to keep looking long after others have stopped.

4
Disease domains mapped
5
Provisional patents filed
3
Clinical-stage products
Cross-domain connections

Medical Research
Solitaire Engine

MRS
Engine
Cancer
Cardio
Neuro
Metabolic

A distributed medical think engine

The MRS Engine uses card game mechanics as a structural metaphor for how biological research is classified, compared, and cross-referenced. Each of the four disease domains corresponds to a suit — enabling systematic mining of cross-domain intersections that no single-discipline approach can replicate.

Outputs are classified through the JELLO insight framework, scored through the Reasonable Man Standard, and captured as drug hypotheses, formulation protocols, and clinical intelligence assets.

01
JELLO Classification Insight moments scored by biological depth (Red → Violet) and cross-domain source discipline
02
AAD Scanner v2.0 MeSH, SNOMED-CT, UMLS, Gene Ontology taxonomy layer with ETL-style pipeline staging
03
Reasonable Man Standard Human-judgment quality filter ensuring every hypothesis meets a defensible evidentiary threshold
04
Version-Controlled Discovery Logs Every hypothesis is timestamped, versioned, and preserved as intellectual property evidence

Four hypotheses.
One engine.

Metabolic ♣
InsuLes
Precision metabolic support for insulin sensitivity
A multi-mechanism formulation targeting insulin signaling through Berberine HCl, Gymnema Sylvestre, Chromium Picolinate, Alpha Lipoic Acid, and BioPerine-enhanced bioavailability. Developed from MRS cross-domain analysis of metabolic pathway intersections.
Provisional Patent Metabolic Clinical-Stage
Metabolic / GLP-1 ♣
Leapsin
The GLP-1 step-down bridge
Positioned as a physician-supervised bridge therapy for patients transitioning off GLP-1 agonists. Leapsin™ supports weight maintenance and appetite regulation during the critical off-ramp period — addressing one of the fastest-growing unmet needs in metabolic medicine.
Provisional Patent GLP-1 Adjunct Highest NTM Value
Ophthalmology / Immunology ♦
ZeaCyte
Zeaxanthin + CD8 T cell modulation for AMD
A novel hypothesis connecting zeaxanthin's known macular protective properties to CD8 T cell immune modulation in age-related macular degeneration. Targets early/intermediate dry AMD and neovascular wet AMD through a dual-mechanism approach.
Provisional Patent Ophthalmology Immunomodulatory
Platform Technology ♠♥♦♣
MRS Engine
The core discovery intelligence platform
The Medical Research Solitaire Engine is the underlying IP that generates and classifies all Foundry One Sciences hypotheses. Licensed to research institutions, physician networks, and pharmaceutical partners as a clinical decision support and drug discovery accelerator.
Core IP SaMD Framework Licensable
View full platform architecture  →

Science doesn't
have one audience.

🔬
For Physicians
Clinical decision support and evidence-based product intelligence for practitioners working at the edge of metabolic, ophthalmologic, and metabolic disease management.
  • Physician-review product dossiers
  • HIPAA-compliant MRS Engine integration
  • GLP-1 step-down protocol support
  • AMD early intervention evidence base
📊
For Investors
A capital-efficient, IP-first drug hypothesis company with a defensible patent portfolio, clear acquisition targets, and a licensing model built for scale.
  • Five provisional patents filed
  • Conservative–blue sky buyout range: $5M–$500M+
  • SBIR / STTR eligible
  • Delaware C-Corp conversion ready
🧬
For Patients & Public
Understanding your options shouldn't require a medical degree. Our products are developed with transparency, evidence, and the patient's journey in mind.
  • Plain-language product guides
  • Evidence behind each formulation
  • Ask your physician resources
  • Updates as science advances
MRS HealthPassport™

Your entire medical history.
In your wallet.

A credentialed QR card that travels with the patient — readable offline in an ambulance, instantly at any MRS-enrolled physician, anywhere in the country.

No phone calls. No fax. No family member trying to remember medications at 2 AM. The card encodes a structured UUID with two layers of clinical data — one offline, one linked to the full chart in the MRS Engine.

"No patient name, date of birth, or address ever enters the system. Just the clinical data needed to save a life."
<6s
Scan to display
0
Patient identifiers stored
2
Encoded layers
30%
QR damage tolerance
EMS · Offline Mode
Ready to Scan
Point at MRS HealthPassport card
Reading QR Code...
🔒 Layer 2 Requires Physician Credential
Enter NPI to unlock
full chart access.
Layer 1 emergency data is ready. To access the complete longitudinal chart, enter your National Provider Identifier. Validated live against the federal NPPES registry — only a licensed physician unlocks Layer 2.
✓ Physician Verified — NPPES Federal Registry
Layer 1 data already displayed below. Continue with Layer 1 only →
Layer 1 · Offline MRS-M-04-NE-XX-A3F7-9C21-K4

Two layers. One card. Zero names.

Layer 1 · Offline Emergency
What a paramedic sees

Decoded offline by any MRS-credentialed scanner. No network. No delay. Available from the moment of scan — in an ambulance, in the field, before the hospital.

Structured UUID with demographic metadata
Blood type (ABO/Rh)
Active medications — drug code + dose
Active diagnoses — ICD-10, top 5 by severity
Known allergies
Attending physician — MRS credential code only
Last physician visit date & zone
Emergency contact flag
Layer 2 · Full Chart Pointer
What a physician sees

Requires active network and physician portal credential. Retrieves the complete longitudinal history from the MRS Engine — every visit, every lab, every protocol change.

Complete visit history — all enrolled physicians
Full lab results and progression timeline
Prior medication changes with dates
Active MRS research briefs on file
Emergency contact details
Cross-domain clinical flags from MRS Engine

One platform. Three environments.

Layer 1 · Offline
🚑
Ambulance / EMS

Battery-powered, offline-first. Full emergency data before the hospital. No network required.

ScannerRAK12018 + LoRaWAN Core
DisplayRuggedized tablet via BLE
NetworkOffline — none required
Layer 1+2 · Full
🏥
Physician Office

Front desk scan at check-in. Layer 1 instant. Layer 2 loads full chart. Physician walks in already knowing the complete history.

ScannerRAK12018 + WiFi Core
DisplayiPad — MRS portal app
NetworkWiFi / LAN
Layer 1+2 · Full
🚨
Hospital / ER

Triage desk or trauma bay. Cellular LTE-M keeps the unit live anywhere in the building. Full chart at point of care.

ScannerRAK12018 + LTE-M Core
DisplayWall tablet at triage
NetworkCellular LTE-M

The conversation
starts here.

Whether you're a physician exploring clinical tools, an investor evaluating the portfolio, or a patient looking for answers — Foundry One Sciences is built to engage at every level of the science.

Founder
Frederick W. Cover II
Location
Catonsville, MD · Delaware LLC
Domain
FoundryOneSciences.com
Entity
SDVOSB · Micro Entity · SBIR Eligible